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Authordc.contributor.authorCastro Castillo, Vicente 
Authordc.contributor.authorSuárez Rozas, Cristian es_CL
Authordc.contributor.authorPabón, Adriana es_CL
Authordc.contributor.authorPérez, Edwin G. es_CL
Authordc.contributor.authorCassels Niven, Brucees_CL
Authordc.contributor.authorBlair, Silvia es_CL
Cita de ítemdc.identifier.citationBioorganic & Medicinal Chemistry Letters 23 (2013) 327–329en_US
Identifierdc.identifier.otherDOI: 10.1016/j.bmcl.2012.10.092
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractSome synthetic 1-azabenzanthrones (7H-dibenzo[de,h]quinolin-7-ones) are weakly to moderately cytotoxic, suggesting that they might also show antiparasitic activity. We have now tested a small collection of these compounds in vitro against a chloroquine-resistant Plasmodium falciparum strain, comparing their cytotoxicity against normal human fibroblasts. Our results indicate that 5-methoxy-1-azabenzanthrone and its 2,3-dihydro analogue have low micromolar antiplasmodial activities and showed more than 10-fold selectivity against the parasite, indicating that the dihydro compound, in particular, might serve as a lead compound for further development.en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Títulodc.titleSynthesis and antiplasmodial activity of some 1-azabenzanthrone derivativesen_US
Document typedc.typeArtículo de revistaen_US

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile