Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+
| Author | dc.contributor.author | García Beltrán, Olimpo | |
| Author | dc.contributor.author | Mena, Natalia P. | es_CL |
| Author | dc.contributor.author | Yáñez, Osvaldo | es_CL |
| Author | dc.contributor.author | Caballero, Julio | es_CL |
| Author | dc.contributor.author | Vargas Cortés, Víctor | es_CL |
| Author | dc.contributor.author | Núñez González, Marco | es_CL |
| Author | dc.contributor.author | Cassels Niven, Bruce | es_CL |
| Admission date | dc.date.accessioned | 2014-01-28T15:06:43Z | |
| Available date | dc.date.available | 2014-01-28T15:06:43Z | |
| Publication date | dc.date.issued | 2013 | |
| Cita de ítem | dc.identifier.citation | European Journal of Medicinal Chemistry 67 (2013) 60e63 | en_US |
| Identifier | dc.identifier.other | doi: 10.1016/j.ejmech.2013.06.022 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/119721 | |
| General note | dc.description | Artículo de publicación ISI | en_US |
| Abstract | dc.description.abstract | A new coumarin-based ‘turn-off’ fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl) propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2þ) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2þ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. | en_US |
| Lenguage | dc.language.iso | en_US | en_US |
| Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | * |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| Keywords | dc.subject | Fe2þ ion | en_US |
| Título | dc.title | Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+ | en_US |
| Document type | dc.type | Artículo de revista |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile