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Authordc.contributor.authorCastro Castillo, Vicente 
Authordc.contributor.authorSuárez Rozas, Cristian es_CL
Authordc.contributor.authorCastro Loiza, Natalia es_CL
Authordc.contributor.authorTheoduloz, Cristina es_CL
Authordc.contributor.authorCassels Niven, Bruce es_CL
Cita de ítemdc.identifier.citationEuropean Journal of Medicinal Chemistry 62 (2013) 688-692en_US
Identifierdc.identifier.otherdoi: 10.1016/j.ejmech.2013.01.049
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractAnthraquinone derivatives are well-known antiproliferative compounds, and some are currently used in cancer chemotherapy. Some families of annulated anthraquinone analogs have also been examined for antiproliferative activity, but in this regard almost nothing is known of 1-azabenzanthrones (7H-dibenzo [de,h]quinolin-7-ones). A series of 1-azabenzanthrone derivatives, their 2,3-dihydro analogs, and congruently substituted 9,10-anthracenediones were tested against normal human fibroblasts and four human cancer cell lines. Most of the heterocyclic compounds proved to be weakly to moderately antiproliferative with 1050 values extending down to 0.86 mu M, and exhibited up to 30-fold selectivity between cancer and normal cells. Both 1-azabenzanthrones and 1-aza-2,3-dihydrobenzanthrones were more potent than their anthraquinone counterparts, and almost without exception, the 2,3-dihydro compounds were more potent than the fully aromatic 1-azabenzanthronesen_US
Patrocinadordc.description.sponsorshipMeceSup (UMCE-0204) fellowship. This work was supported by CONICYT grant AT-23070040 and ICM grant P05-001-F.en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Títulodc.titleAnnulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compoundsen_US
Document typedc.typeArtículo de revista

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile