Septin 7 - Actin cross-organization is required for axonal association of Schwann cells
Author
dc.contributor.author
Roth Metcalfe, Alejandro Darío
Author
dc.contributor.author
Liazoghli, Dalinda
es_CL
Author
dc.contributor.author
Pérez de Arce, Felipe
es_CL
Author
dc.contributor.author
Colman, David R.
es_CL
Admission date
dc.date.accessioned
2014-03-13T19:36:49Z
Available date
dc.date.available
2014-03-13T19:36:49Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
Biol Res 46: 243-249, 2013
en_US
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/119792
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
Myelin sheaths present two distinct domains: compacted myelin spirals and fl anking non-compacted cytoplasmic channels, where lipid
and protein segregation is established by unknown mechanisms. Septins, a conserved family of membrane and cytoskeletal interacting
GTPases, form intracellular diff usion barriers during cell division and neurite extension and are expressed in myelinating cells. Septins,
particularly septin 7 (Sept7), the central constituent of septin polymers, are associated with the cytoplasmic channels of myelinating
cells. Here we show that Schwann cells deprived of Sept7 fail to wrap around axons from dorsal root ganglion neurons and exhibit
disorganization of the actin cytoskeleton. Likewise, Sept7 distribution is dependent on microfi lament but not microtubule organization.