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Authordc.contributor.authorGarcía Beltrán, Olimpo 
Authordc.contributor.authorCassels Niven, Brucees_CL
Authordc.contributor.authorMena, Natalia P. es_CL
Authordc.contributor.authorNúñez González, Marco es_CL
Authordc.contributor.authorYáñez, Osvaldo es_CL
Authordc.contributor.authorCaballero, Julio es_CL
Cita de ítemdc.identifier.citationTetrahedron Letters 55 (2014) 873-876en_US
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractIn this Letter we present a new probe, (E)-7-(diethylamino)-2-oxo-2H-chromene-3-carbaldehyde oxime (JB), which can detect Cu2+ ions in HEPES buffer under physiological conditions. Benesi–Hildebrand and Job plots demonstrate that the stoichiometry of the Cu2+ complex formed is 2:1. Possible interference with other analytes was examined, and the decrease of the fluorescence of JB at 510 nm when it reacts with Cu2+ was shown to be highly selective. This probe accumulates in the plasmalemma of human neuroblastoma SH-SY5Y cells. Molecular dynamics (MD) simulations revealed that JB interacts with the lipid bilayer at the level of the glycerol moieties.en_US
Patrocinadordc.description.sponsorshipFONDEF VIU-110063. FONDECYT Grant # 1130141.en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Títulodc.titleA coumarinylaldoxime as a specific sensor for Cu2+ and its biological applicationen_US
Document typedc.typeArtículo de revistaen_US

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile