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Authordc.contributor.authorGarcía Beltrán, Olimpo 
Authordc.contributor.authorYáñez, Osvaldo es_CL
Authordc.contributor.authorCaballero, Julio es_CL
Authordc.contributor.authorGaldámez Silva, Antonio es_CL
Authordc.contributor.authorMena, Natalia P. es_CL
Authordc.contributor.authorNúñez González, Marco es_CL
Authordc.contributor.authorCassels Niven, Bruce es_CL
Admission datedc.date.accessioned2014-12-11T12:49:52Z
Available datedc.date.available2014-12-11T12:49:52Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationEuropean Journal of Medicinal Chemistry 76 (2014) 79e86en_US
Identifierdc.identifier.otherdx.doi.org/10.1016/j.ejmech.2014.02.016
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/119806
General notedc.descriptionArticulo de publicacion SCOPUSen_US
Abstractdc.description.abstractThree coumarin-derived fluorescent probes, 3-acetyl-7-[(6-bromohexyl)oxy]-2H-chromen-2-one (FM1), 7-[(6-bromohexyl)oxy]-4-methyl-2H-chromen-2-one (FM2) and ethyl 2-{7-[(6-bromohexyl)oxy]-2-oxo- 2H-chromen-4-yl}acetate (FM3), are described, with their photophysical constants. The compounds were tested in preliminary studies employing epifluorescence microscopy demonstrating that they allow the imaging of human neuroblastoma SH-SY5Y cell membranes. The structure of FM3 was confirmed by X-ray crystallographic analysis. Molecular dynamics (MD) simulations were used to characterize the localization and interactions of the studied compounds with a lipid bilayer model of 1-palmitoyl-2- oleoyl-sn-glycero-3-phosphocholine (POPC).en_US
Patrocinadordc.description.sponsorshipFONDECYTen_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherElsevieren_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectCoumarinsen_US
Títulodc.titleSynthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studiesen_US
Document typedc.typeArtículo de revistaen_US


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile