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Authordc.contributor.authorGarcía Beltrán, Olimpo 
Authordc.contributor.authorCassels Niven, Brucees_CL
Authordc.contributor.authorPérez, Claudio es_CL
Authordc.contributor.authorMena, Natalia P. es_CL
Authordc.contributor.authorNúñez González, Marco es_CL
Authordc.contributor.authorMartínez, Natalia P. es_CL
Authordc.contributor.authorPizarro Pavez, Paulina Ignacia 
Authordc.contributor.authorAliaga, Margarita E. 
Admission datedc.date.accessioned2014-12-19T02:49:52Z
Available datedc.date.available2014-12-19T02:49:52Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationSensors 2014, 14, 1358-1371en_US
Identifierdc.identifier.otherDOI: 10.3390/s140101358
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/119844
General notedc.descriptionArtículo de publicación ISien_US
Abstractdc.description.abstractTwo new coumarin-based “turn-off” fluorescent probes, (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS1) and (E)-3-((2,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS2), were synthesized and their detection of copper(II) and iron(III) ions was studied. Results show that both compounds are highly selective for Cu2+ and Fe3+ ions over other metal ions. However, BS2 is detected directly, while detection of BS1 involves a hydrolysis reaction to regenerate 3-amino-7-hydroxycoumarin (3) and 3,4-dihydroxybenzaldehyde, of which 3 is able to react with copper(II) or iron(III) ions. The interaction between the tested compounds and copper or iron ions is associated with a large fluorescence decrease, showing detection limits of ca. 10−5 M. Preliminary studies employing epifluorescence microscopy demonstrate that Cu2+ and Fe3+ ions can be imaged in human neuroblastoma SH-SY5Y cells treated with the tested probes.en_US
Patrocinadordc.description.sponsorshipThis work was supported by FONDECYT Grant #1130062 and by FONDEF VIU-110063.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherMDPIen_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectCu2+ ionen_US
Títulodc.titleCoumarin-Based Fluorescent Probes for Dual Recognition of Copper(II) and Iron(III) Ions and Their Application in Bio-Imagingen_US
Document typedc.typeArtículo de revistaen_US


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile