About
Contact
Help
Sending publications
How to publish
Advanced Search
View Item 
  •   Home
  • Facultad de Ciencias Químicas y Farmacéuticas
  • Artículos de revistas
  • View Item
  •   Home
  • Facultad de Ciencias Químicas y Farmacéuticas
  • Artículos de revistas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse byCommunities and CollectionsDateAuthorsTitlesSubjectsThis CollectionDateAuthorsTitlesSubjects

My Account

Login to my accountRegister
Biblioteca Digital - Universidad de Chile
Revistas Chilenas
Repositorios Latinoamericanos
Tesis LatinoAmericanas
Tesis chilenas
Related linksRegistry of Open Access RepositoriesOpenDOARGoogle scholarCOREBASE
My Account
Login to my accountRegister

Absorption kinetics of acetylsalicylic acid in gastrectomized patients

Artículo
Thumbnail
Open/Download
IconHURTADO_1988.pdf (2.811Mb)
Publication date
1988
Metadata
Show full item record
Cómo citar
Hurtado Heim, Carmen
Cómo citar
Absorption kinetics of acetylsalicylic acid in gastrectomized patients
.
Copiar
Cerrar

Author
  • Hurtado Heim, Carmen;
  • Acevedo, Carlos;
  • Domecq Jeldres, Catalina;
  • Burdiles Pinto, Patricio;
  • Csendes Juhasz, Attila;
  • Arancibia, Aquiles;
Abstract
Acetylsalicylic acid (ASA) is one of the oldest and most widely used medicinal agents today and its spectrum of therapeutic use is continually widening. Although many other drugs have been introduced during the last few years, ASA remains in a prominent position as the standard analgesic, antipyretic and anti-inflammatory drug of choice [1,2]. Gastrectomy consists of a partial or total surgical resection of the stomach, and the continuity of intestinal transit is re-established by means of the anastomosis of the remainder of the stomach with a gastro-duodenostomy (anastomosis Billroth Type I) or by a gastro-jejunostomy (Billroth Type II). When total gastrectomy is performed the intestinal transit continuity is re-established by directly connecting the esophagus with the jejunum (esophagus-jejunostomy)[13]. Orally administered ASA is rapidly and usually completely absorbed from the gastrointestinal tract. Absorption occurs by passive diffusion of unionized lipophilic molecules, partially from the stomach but mainly from the upper small intestine [4]. Gastrointestinal pH has a major influence on the rate of absorption of ASA by the two different mechanisms. At first low pH in the stomach provides optimum conditions for the absorption of undissociated ASA molecules. Then, as pH rises in the small intestine, the dissolution rate of ASA solid particles increases and is maximal at Ph8[4]. In Chile a large number of patients have undergone gastrectomy because of gastroduodenal disease. A clearer understanding of ASA absorption kinetics is therefore of great importance for the establishment of a safe an effective dose regimen for both acute and long term therapy of gastrectomized patients as well as subjects with normal gastrointestinal function [5].
Identifier
URI: https://repositorio.uchile.cl/handle/2250/121177
ISSN: 0269-8951
Quote Item
Medical Science Research 16: 1241-1243
Collections
  • Artículos de revistas
xmlui.footer.title
31 participating institutions
More than 73,000 publications
More than 110,000 topics
More than 75,000 authors
Published in the repository
  • How to publish
  • Definitions
  • Copyright
  • Frequent questions
Documents
  • Dating Guide
  • Thesis authorization
  • Document authorization
  • How to prepare a thesis (PDF)
Services
  • Digital library
  • Chilean academic journals portal
  • Latin American Repository Network
  • Latin American theses
  • Chilean theses
Dirección de Servicios de Información y Bibliotecas (SISIB)
Universidad de Chile

© 2020 DSpace
  • Access my account