Author | dc.contributor.author | Navarrete, Mario | |
Author | dc.contributor.author | Núñez, Héctor | es_CL |
Author | dc.contributor.author | Ruiz, Samuel | es_CL |
Author | dc.contributor.author | Soto Moyano, Rubén | es_CL |
Author | dc.contributor.author | Valladares Boasi, Luis | es_CL |
Author | dc.contributor.author | White Ortiz, Allan | es_CL |
Author | dc.contributor.author | Pérez, Hernán | es_CL |
Admission date | dc.date.accessioned | 2009-06-23T16:58:50Z | |
Available date | dc.date.available | 2009-06-23T16:58:50Z | |
Publication date | dc.date.issued | 2007-05 | |
Cita de ítem | dc.identifier.citation | NEUROSCIENCE LETTERS, V.: 419, issue: 2, p.: 99-103, MAY 29 2007. | en |
Identifier | dc.identifier.issn | 0304-3940 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/123899 | |
Abstract | dc.description.abstract | Prenatal undernutrition is known to disturb the hypothalamo-pituitary-adrenal (HPA) axis, possibly through the programming of decreased
expression of hypothalamic and pituitary glucocorticoid receptors. To test this hypothesis, we examined the corticosterone response to moderate
subcutaneous (100 g/kg) and intra-paraventricular (50 pmol, bilaterally) dexamethasone (DEX) challenges in normal eutrophic and prenatally
undernourished young rats. Undernutrition was induced during fetal life by restricting the diet of pregnant mothers to 10 g daily, while mothers
of eutrophic rats received the same diet ad libitum. At day 40 of postnatal life (i) undernourished rats showed increased plasma corticosterone
concentration compared to normals; and (ii) subcutaneous and intra-paraventricular administrations of DEX led to reduced corticosterone levels
in normal and undernourished animals, the effect of DEX (administered either peripherally or centrally) being significantly lower in the latter
group. Results suggest that the low sensitivity of the HPA axis to DEX as well as the increased plasma corticosterone observed in prenatally
undernourished rats could be due to the already reported glucocorticoid receptor underexpression found in the hypothalamus and pituitary of in
utero undernourished animals, but alternative explanations involving central noradrenergic adaptive changes could also be possible.
© 2007 Elsevier Ireland Ltd. All rights reserved. | en |
Patrocinador | dc.description.sponsorship | This study was supported by grant no. 1030626 from Fondecyt | en |
Lenguage | dc.language.iso | en | en |
Publisher | dc.publisher | ELSEVIER IRELAND LTD, ELSEVIER HOUSE | en |
Keywords | dc.subject | Prenatal undernutrition | en |
Título | dc.title | Prenatal undernutrition decreases the sensitivity of the pituitary-adrenal axis in rat, as revealed by subcutaneous and intra-paraventricular dexamethasone challenges | en |
Document type | dc.type | Artículo de revista | |