| Abstract | dc.description.abstract | The aim of this study was to examine the relationship between
total daily fluoride intake (TDFI), daily urinary fluoride
excretion (DUFE) and fractional fluoride retention (FFR) using
available data, in order to clarify the ability of DUFE to
predict TDFI and, therefore, the risk of fluorosis development.
Examination of published reports of simultaneous
measurement of TDFI and DUFE, together with data from
two unpublished Chilean studies, yielded data for 212 children
aged less than 7 years and for 283 adults aged 18–75
years, providing a total of 212 and 269 data points, respectively.
The relationship between DUFE and TDFI was studied
for children and adults, separately. Daily fluoride retention
(DFR) was estimated as a function of TDFI in children and
adults assuming an average 90% fluoride absorption, and
the numerical relationships between the estimated FFR and
the TDFI were explored. Limiting FFR values of 0.55 and 0.36
were found for children and adults, respectively, above a
threshold of TDFI of 0.5 and 2 mg, respectively. Neutral fluoride
balances were predicted when the TDFI was equal to
approximately 0.07 mg F/day for children and 0.8 mg F/day
for adults. For children and adults, it is possible to obtain reasonably good estimations of community-based TDFI and
DFR, using DUFE data. The advantages and limitations of
these relationships, together with the need for future studies,
are discussed. | en_US |
