Author | dc.contributor.author | Zepeda Iriarte, Ramiro | |
Author | dc.contributor.author | Castillo, Paula | es_CL |
Author | dc.contributor.author | Sáez, Daniel | es_CL |
Author | dc.contributor.author | Llanos Silva, Miguel | es_CL |
Author | dc.contributor.author | Ronco Macchiavello, Ana María | es_CL |
Admission date | dc.date.accessioned | 2012-07-31T21:37:29Z | |
Available date | dc.date.available | 2012-07-31T21:37:29Z | |
Publication date | dc.date.issued | 2012 | |
Cita de ítem | dc.identifier.citation | Cardiovasc Toxicol (2012) 12:64–72 | es_CL |
Identifier | dc.identifier.other | DOI 10.1007/s12012-011-9139-6 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/124016 | |
General note | dc.description | Artículo de publicación ISI | es_CL |
Abstract | dc.description.abstract | It has been suggested that prenatal exposure to
cadmium may alter the cardiovascular function during
adulthood. Using the left coronary artery ligation model of
acute myocardial infarction, we studied the cardiac function
of female adult offspring rats exposed to cadmium
(30 ppm) during gestation. The cardiac ischemic zone in
the control and cadmium-exposed groups was measured
72 h post-ligation using the TPT staining technique. Offspring
from cadmium-treated dams showed a significantly
smaller infarcted area compared with the control group
(7.1 ± 1.5 vs. 19.6 ± 2.8%, P B 0.05). We also performed
echocardiographic and biochemical studies, which
positively correlated with the differences observed previously.
To evaluate whether the effects were associated to
pre-infarct tissue damage and/or angiogenic molecules, we
performed histological studies and measured the expression
of vascular endothelial growth factor (VEGF), and platelet
endothelial cellular adhesion molecule-1 (PECAM-1).
Results revealed a higher heart vascularization in the
exposed offspring that was associated with an increase in
PECAM and a decrease in VEGF expression. We conclude
that prenatal exposure to cadmium induces fetal adaptive
responses involving changes in the expression of some
cardiac angiogenic molecules resulting in long-term resistance
to infarction. | es_CL |
Patrocinador | dc.description.sponsorship | Fondo Nacional de
Ciencia y Tecnologı´a (FONDECYT) No. 1100168 to AMR. | es_CL |
Lenguage | dc.language.iso | en | es_CL |
Publisher | dc.publisher | Springer | es_CL |
Keywords | dc.subject | Cadmium | es_CL |
Título | dc.title | Cardiac Tissue Injury Resistance During Myocardial Infarction at Adulthood by Developmental Exposure to Cadmium | es_CL |
Document type | dc.type | Artículo de revista | |