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Authordc.contributor.authorSantibáñez, Juan Francisco 
Authordc.contributor.authorQuintanilla, Miguel es_CL
Authordc.contributor.authorMartínez, Jorge es_CL
Cita de ítemdc.identifier.citationFEBS Letters 520 (2002) 171^176en_US
Identifierdc.identifier.otherPII: S 0 0 1 4 - 5 7 9 3 ( 0 2 ) 0 2 7 6 0 - 6
Abstractdc.description.abstractWe have examined the effect of transforming growth factor L1 (TGF-L1) and overexpression of the Smad4 gene on the phenotype of Car C, a ras mutated highly malignant spindle carcinoma cell line. TGF-L1-treated Car C cells overexpressing Smad4 spread with a flattened morphology with membrane ruffles abundant in vinculin and show a reduction in their invasive abilities. TGF-L1 treatment and overexpression of Smad4 also enhanced the production of PAI-1 measured by the activation of the p3TP-lux reporter gene containing a PAI-1- related promoter. This activation was abolished with a dominant-negative Smad4 construct. These results lead us to conclude that both TGF-L1 and Smad4 overexpression reduce the invasive potential of Car C cells, probably via the Smad pathway. ' 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.en_US
Publisherdc.publisherElsevier Science B.V. on behalf of the Federation of European Biochemical Societies.en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectTGF-B1 ; Smad4; Spindle; Cat Cen_US
Títulodc.titleTGF-L1 and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cellsen_US
Document typedc.typeArtículo de revista

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile