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Autordc.contributor.authorMartínez Winkler, Jorge 
Autordc.contributor.authorFuentes, Mauricio es_CL
Autordc.contributor.authorCambiazo Ayala, Liliana es_CL
Autordc.contributor.authorSantibáñez, J. Francisco es_CL
Fecha ingresodc.date.accessioned2014-01-08T19:27:05Z
Fecha disponibledc.date.available2014-01-08T19:27:05Z
Fecha de publicacióndc.date.issued1999-10-08
Cita de ítemdc.identifier.citationInt. J. Cancer: 83, 278–282 (1999)en_US
Identificadordc.identifier.issn0020-7136
Identificadordc.identifier.otherDOI: 10.1002/(SICI)1097-0215(19991008)83:2<278::AID-IJC21>3.3.CO;2-Z
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/124049
Nota generaldc.descriptionArtículo de publicación ISIen_US
Resumendc.description.abstractBone is the most frequent site of metastasis in breast cancer. This causes destructive osteolytic lesions. To achieve metastasis to bone, breast cancer cells must proliferate in a new microenvironment, arrest on extracellular matrix and invade. Breast cancer cells progress in the invasive processes only if they destroy bone with the assistance of osteoclasts. In this work, we present data suggesting that MCF-7 cells, an estradiol receptor–positive cell line that exhibits modest invasive capacity, proliferate in the presence of soluble factors secreted by the osteogenic cell line SaOS-2. The cells acquire a more aggressive phenotype when cultured on an extracellular matrix produced by the same osseous cell line. Acquisition of the invasive phenotype appears to be related to the capacity of bone extracellular matrix to induce the expression of urokinase-like plasminogen activator by MCF-7 cells, which is specific for MCF-7 cells, given that MDA-231 cells, an estradiol receptor–negative and more aggressive cell line, did not show significant changes when cultured in the presence of soluble and insoluble bone factors.en_US
Patrocinadordc.description.sponsorshipThis work was supported by grant 8970028 from Fondo de Desarrollo de Ciencia y Tecnologia (FONDECYT, to JM) and by FONDECYT 1980262 (to VC).en_US
Idiomadc.language.isoenen_US
Publicadordc.publisherWILEY-LISS, DIV JOHN WILEY & SONS INCen_US
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Palabras clavesdc.subjectNeoplasmas de las mamas--Complicacionesen_US
Títulodc.titleBONE EXTRACELLULAR MATRIX STIMULATES INVASIVENESS OF ESTROGEN-RESPONSIVE HUMAN MAMMARY MCF-7 CELLSen_US
Tipo de documentodc.typeArtículo de revista


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Attribution-NonCommercial-NoDerivs 3.0 Chile
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