Iron-deficiency anemia in infancy and poorer cognitive inhibitory control at age 10 years
Author
dc.contributor.author
Algarín Crespo, Cecilia Rosa
Author
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Nelson, Charles A.
es_CL
Author
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Peirano Campos, Patricio
es_CL
Author
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Westerlund, Elissa
es_CL
Author
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Reyes, Sussanne
es_CL
Author
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Lozoff, Betsy
es_CL
Admission date
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2014-02-10T14:48:24Z
Available date
dc.date.available
2014-02-10T14:48:24Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
Developmental Medicine & Child Neurology 2013, 55: 453–458
en_US
Identifier
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DOI: 10.1111/dmcn.12118
Identifier
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https://repositorio.uchile.cl/handle/2250/124095
General note
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Artículo de publicación ISI
en_US
Abstract
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AIM The aim of this study was to assess the effects of iron-deficiency anemia (IDA) in infancy
on executive functioning at age 10 years, specifically inhibitory control on the Go/No-Go task.
We predicted that children who had IDA in infancy would show poorer inhibitory control.
METHOD We assessed cognitive inhibitory control in 132 Chilean children (mean [SD] age
10y [1mo]): 69 children had IDA in infancy (45 males, 24 females) and 63 comparison children
who did not have IDA (26 males, 37 females). Participants performed the Go/No-Go task with
event-related potentials. Group differences in behavioral (accuracy, reaction time) and
electrophysiological outcomes (N2 and P300 components) were analyzed using repeatedmeasures
analyses of variance. N2 and P300 are interpreted to reflect attention and resource
allocation respectively.
RESULTS Relative to comparison participants, children who had IDA in infancy showed
slower reaction time (mean [SE], 528.7ms [14.2] vs 485.0ms [15.0], 95% confidence interval
[CI] for difference between groups 0.9–86.5); lower accuracy (95.4% [0.5] vs 96.9% [0.6], 95%
CI 3.0 to 0.1); longer latency to N2 peak (378.9ms [4.9] vs 356.9ms [5.0], 95% CI 7.5–36.6);
and smaller P300 amplitude (4.5lV [0.8] vs 7.6lV [0.9], 95% CI 5.5 to 0.5).
INTERPRETATION IDA in infancy was associated with slower reaction times and
poorer inhibitory control 8 to 9 years after iron therapy. These findings are consistent with
the long-lasting effects of early IDA on myelination and/or prefrontal–striatal circuits where
dopamine is the major neurotransmitter.