Lipid Needs of Preterm Infants: Updated Recommendations
Author
dc.contributor.author
Lapillonne, Alexandre
Author
dc.contributor.author
Groh-Wargo, Sharon
es_CL
Author
dc.contributor.author
Lozano Gonzalez, Carlos H.
es_CL
Author
dc.contributor.author
Uauy Dagach-Imbarack, Ricardo
es_CL
Admission date
dc.date.accessioned
2014-02-11T13:53:40Z
Available date
dc.date.available
2014-02-11T13:53:40Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
J Pediatr 2013;162:S37-47
en_US
Identifier
dc.identifier.other
doi 10.1016/j.jpeds.2012.11.052
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/124100
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
Long-chain polyunsaturated fatty acids (LCPUFAs) are of nutritional interest because they are crucial for normal development
of the central nervous system and have potential long-lasting effects that extend beyond the period of
dietary insufficiency. Here we review the recent literature and current recommendations regarding LCPUFAs as
they pertain to preterm infant nutrition. In particular, findings that relate to fetal accretion, LCPUFA absorption
and metabolism, effects on development, and current practices and recommendations have been used to update
recommendations for health care providers.
The amounts of long-chain polyunsaturated fatty acids (LCPUFAs) used in early studies were chosen to produce
the same concentrations as in term breast milk. This might not be a wise approach for preterm infants, however,
particularly for very and extremely preterm infants, whose requirements for LCPUFAs and other nutrients exceed
what is normally provided in the small volumes that they are able to tolerate. Recent studies have reported outcome
data in preterm infants fed milk with a docosahexaenoic acid (DHA) content 2-3 times higher than the current concentration
in infant formulas. Overall, these studies show that providing larger amounts of DHA supplements, especially
to the smallest infants, is associated with better neurologic outcomes in early life. We emphasize that
current nutritional management might not provide sufficient amounts of preformed DHA during the parenteral
and enteral nutrition periods and in very preterm/very low birth weight infants until their due date, and that greater
amounts than used routinely likely will be needed to compensate for intestinal malabsorption, DHA oxidation, and
early deficit. Research should continue to address the gaps in knowledge and further refine adequate intake for
each group of preterm infants.