Release of Prednisolone and Inulin from a New Calcium-Alginate Chitosan-Coated Matrix System for Colonic Delivery
Author
dc.contributor.author
Araujo, Valeria
Author
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Gamboa, Alexander
es_CL
Author
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Caro, Nelson
es_CL
Author
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Abugoch James, Lilian
es_CL
Author
dc.contributor.author
Gotteland, Martín
es_CL
Author
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Valenzuela, Fernando
es_CL
Author
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Merchant, Hamid A.
es_CL
Author
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Basit, Abdul W.
es_CL
Author
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Tapia, Cristián
es_CL
Admission date
dc.date.accessioned
2014-03-12T14:43:16Z
Available date
dc.date.available
2014-03-12T14:43:16Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
J Pharm Sci 102:2748–2759, 2013
en_US
Identifier
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DOI 10.1002/jps.23656
Identifier
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https://repositorio.uchile.cl/handle/2250/124106
General note
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Artículo de publicación ISI
en_US
Abstract
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Putative colonic release formulations of calcium (Ca)-alginate coated with chitosan
containing two different actives, prednisolone and inulin, were prepared in three different
sizes, beads (D50 = 2104 :m) and microparticles (D50 = 354 and 136 :m). The formulations were
tested in standard phosphate buffer and biorelevant Krebs bicarbonate buffer at pH 7.4, and
were further evaluated in the presence of the bacterium E. coli. Product yield and encapsulation
were higher with prednisolone than with inulin. In Krebs bicarbonate buffer, a clear
relationship between particle size and prednisolone release was observed. In contrast, release
of inulin was independent of the particle size. In phosphate buffer, the particles eroded quickly,
whereas in Krebs buffer, the particles swelled slowly. The difference in behavior can be attributed
to the formation of calcium phosphate in the phosphate buffer medium, which in turn
weakens the Ca-alginate matrix core. In the presence of E. coli, the formulations were fermented
and the release of prednisolone was accelerated. In conclusion, the buffer media affects formulation
behavior and drug release, with the bicarbonate media providing a better simulation of
in vivo behavior. Moreover, the susceptibility of the formulations to bacterial action indicates
their suitability as carriers for colonic drug delivery.
en_US
Lenguage
dc.language.iso
en
en_US
Publisher
dc.publisher
Wiley Periodicals, and the American Pharmacists Association