Markers of Oxidative Stress and Systemic Vasoconstriction in Pregnant Women Drinking ‡48 g of Alcohol per Day
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2008-11Metadata
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Signore, Caroline
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Markers of Oxidative Stress and Systemic Vasoconstriction in Pregnant Women Drinking ‡48 g of Alcohol per Day
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Abstract
Background: The precise pathway by which alcohol causes the characteristic features of fetal
alcohol spectrum disorders is unknown. Proposed mechanisms for fetal injury from maternal alcohol
use include cellular damage from oxidative stress and impaired fetal oxygenation related to
maternal systemic vasoconstriction. Our objective was to compare the levels of urinary markers
of oxidative stress and systemic vasoconstriction between women consuming large amounts of
alcohol during pregnancy and women who did not drink alcohol during pregnancy.
Methods: Pregnant women consuming ‡48 g alcohol per day (n = 29) on average and pregnant
women who abstained from alcohol use (n = 39) were identified using detailed interviews
and home visits. Random maternal urine specimens were collected. Urinary levels of the oxidative
stress marker, 8-isoprostane F2a, and of the vasoactive prostaglandin metabolites, 2,3-dinor-
6-keto-prostaglandin F1a (a vasodilator) and 11-dehydro-thromboxane B2 (a vasoconstrictor),
were measured using mass spectrometric methods. All analyte levels were corrected for urinary
creatinine.
Results: In crude analyses, there was no significant difference in 8-isoprostane F2a between
pregnant drinkers and nondrinkers (2.16 vs. 2.08 ng ⁄mg creatinine, respectively, p = 0.87). There
were no significant differences between the drinking and nondrinking groups in levels of 2,
3-dinor-6-keto-prostaglandin F1a (1.03 vs. 1.17 ng ⁄ mg creatinine, repectively, p = 0.50),
11-dehydro-thromboxane B2 (0.72 vs. 0.59 ng ⁄ mg creatinine, respectively, p = 0.21), or the ratio
of vasodilatory metabolite to vasoconstrictive metabolite (1.73 vs. 2.72, respectively, p = 0.14).
Adjusting for maternal age, marital status, smoking, and gestational age at sampling did not
substantially alter the results.
Conclusion: Our results show no difference in levels of urinary eicosanoid markers of oxidative
stress and systemic vasoconstriction between pregnant women who drink heavily and pregnant
women who abstain. These findings speak against a role for maternal oxidative stress or systemic
vasoconstriction in the pathogenesis of alcohol damage to the fetus.
Patrocinador
This research was supported by the Intramural Research
Program of the Eunice Kennedy Shriver National Institute of
Child Health and Human Development and by National
Institutes of Health grants GM15431, DK48831 and ES131
25.
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ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Volume: 32, Issue: 11, Pages: 1893-1898, 2008
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