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Sobrecrecimiento bacteriano intestinal en pacientes con pancreatitis crónica

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2008-08
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Mancilla Asencio, Carla
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Sobrecrecimiento bacteriano intestinal en pacientes con pancreatitis crónica
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Author
  • Mancilla Asencio, Carla;
  • Madrid Silva, Ana;
  • Hurtado Heim, Carmen;
  • Orellana B., Carolina;
  • Peña Z., Margarita;
  • Tobar Almonacid, Eduardo;
  • Berger Fleiszig, Zoltán;
Abstract
Previous reports describe 30-40% of small intestine bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP), SIBO is a cause of persistent symptoms in this group of patients even when they are treated with pancreatic enzymes. Aim: To asses the frequency of SIBO in patients with CP. Patients and methods: We studied 14 patients with CP using an hydrogen breath test with lactulose to detect SIBO, a nonabsorbable carbohydrate, whose results are not influenced by the presence of exocrine insufficiency. Main symptoms and signs were bloating in 9 (64%), recurrent abdominal pain in 8 (57%), intermittent diarrhea in 5 (36%) and steatorrhea in 5 (36%). At the same time we studied a healthy control group paired by age and sex. Results: SIBO was present in 13 of 14 patients with CP (92%) and in 1 of 14 controls (p<0.001). The only patient with CP and without SIBO was recently diagnosed and had minimal morphologic alterations in computed tomography and endoscopic pancreatography. Conclusions: SIBO is common in CP and may be responsible for persistent symptoms. Proper diagnosis and treatment could alleviate symptoms and improve quality of life
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URI: https://repositorio.uchile.cl/handle/2250/128372
ISSN: 0034-9887
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REVISTA MEDICA DE CHILE Volume: 136, Issue: 8, Pages: 976-980, 2008
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