Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters

Abstract

Objective: To evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSdþM), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd M) and daughters of women who belong to a healthy comparison group (HCd). Design: Descriptive and analytic study. Setting: Unit of endocrinology and reproductive medicine. Patient(s): Fifteen PCOSdþM, 23 PCOSd M, and 35 HCd were studied at 2–3 months of age. Intervention(s): A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-M€ullerian hormone (AMH). Main Outcome Measure(s): Differences in AMH levels between PCOSdþM, PCOSd M and HCd. Result(s): AMH and peak E2 concentrations were significantly higher in PCOSd M compared with HCd, whereas PCOSdþM exhibited AMH concentrations and peak E2 levels similar to those observed in HCd. Conclusion(s): The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass.