PCA3 sensitivity and specificity for prostate cancer detection in patients with abnormal PSA and/or suspicious digital rectal examination. First Latin American experience
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Ramos, Christian G.
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PCA3 sensitivity and specificity for prostate cancer detection in patients with abnormal PSA and/or suspicious digital rectal examination. First Latin American experience
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Abstract
Introduction: Prostate Cancer Gene 3 (PCA3) is a recently described and highly specific urinary marker for prostate cancer (CaP). Its
introduction in clinical practice to supplement low specificity of prostate specific antigen (PSA) can improve CaP diagnosis and follow-up.
However, before its introduction, it is necessary to validate the method of PCA3 detection in distinct geographic populations.
Objectives: Our aim was to describe for the first time in Latin America, the application of the PROGENSA PCA3 assay for PCA3
detection in urine in Chilean men and its utility for CaP diagnosis in men with an indication of prostate biopsy.
Materials and methods: Sixty-four Chilean patients (mean age, 64 years) with indication of prostate biopsy because of elevated PSA
and/or suspicious digital rectal examination (DRE) were prospectively recruited. PCA3 scores were assessed from urine samples obtained
after DRE, before biopsy, and compared with PSA levels and biopsy outcome.
Results: The median PSA value and mean PCA3 score were 5.8 ng/ml and 31.7, respectively. Using a cutoff PCA3 score of 35, the
sensitivity and specificity for detecting CaP were 52% and 87%, respectively. The receiver operating characteristic (ROC) curve analysis
showed an area under the curve of 0.77 for PCA3 and 0.57 for PSA, for the same group of patients. In patients with previous negative biopsy,
PCA3 specificity increased by 2.2%.
Conclusions: This is the first report in Latin America on the use of PCA3 in diagnosing CaP. Our results are comparable to those
reported in other populations in the literature, demonstrating the reproducibility of the test. PCA3 score was highly specific and we specially
recommend its use in patients with persistent elevated PSA and prior negative biopsies.
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URI: https://repositorio.uchile.cl/handle/2250/129127
DOI: DOI: 10.1016/j.urolonc.2012.05.002
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Urologic Oncology: Seminars and Original Investigations 31 (2013) 1522–1526
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