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Authordc.contributor.authorVera, A. M. 
Authordc.contributor.authorCárcamo, J. J. 
Authordc.contributor.authorAliaga, A. E. 
Authordc.contributor.authorGómez Jeria, Juan 
Authordc.contributor.authorKogan Bocian, Marcelo 
Authordc.contributor.authorCampos Vallette, Marcelo 
Cita de ítemdc.identifier.citationSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 134 (2015) 251–256en_US
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractIn a previous work we demonstrated that toxic aggregates of the protein b-amyloid (ATAb) involved in the Alzheimer’s disease (AD) can be destabilized upon electromagnetic irradiation of the peptide Cys- Leu-Pro-Phe-Phe-Asp (CLPFFD) adsorbed on gold nanospheres (AuNSs). For a selective recognition of the therapeutic target (i.e. ATAb) of AD by the conjugates peptide-nanoparticle it is relevant to understand how the interaction between attached ligands and nanoparticles occurs. In this work a surface enhanced Raman scattering spectroscopy (SERS) study of the interactions of CLPFFD with AuNSs of 10 nm average diameter was carried out. The SERS data suggest that phenylalanine displays its aromatic ring coplanar to the surface which is supported by theoretical data obtained from molecular mechanics (MM) and Extended Hückel Theory (EHT) calculations.en_US
Patrocinadordc.description.sponsorshipFONDECYT-Chile projects 1130425 and 1110106, and FONDAP-Chile 15130011. AMV acknowledges a doctoral fellowship from CONICYT for financial support. JJC acknowledges projects MECESUP UTA-0801, MECESUP UCH-0811 and Convenio de Desempeño HCSA Universidad de Tarapacá-MINEDUC.en_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectCLPFFD peptideen_US
Keywordsdc.subjectPeptide anti-aggregation of b-amyloiden_US
Keywordsdc.subjectSERS Extended Hückelen_US
Keywordsdc.subjectTheory calculationsen_US
Títulodc.titleInteraction of the CLPFFD peptide with gold nanospheres. A Raman, surface enhanced Raman scattering and theoretical studyen_US
Document typedc.typeArtículo de revista

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile