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Authordc.contributor.authorBunout Barnett, Daniel 
Authordc.contributor.authorBarrera Acevedo, Maria 
Authordc.contributor.authorMaza Cave, María Pía de la 
Authordc.contributor.authorLeiva, L. 
Authordc.contributor.authorHirsch Birn, Sandra 
Admission datedc.date.accessioned2015-08-11T14:04:07Z
Available datedc.date.available2015-08-11T14:04:07Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationJournal of Human Nutrition and Dietetics, Volumen: 28 Número: 2 Páginas: 155-164, Apr 2015en_US
Identifierdc.identifier.otherDOI: 10.1111/jhn.12231
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/132566
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractBackground: Lack of weight gain throughout adult life could mimic the beneficial effects of energy restriction in humans. The present study aimed to assess the effects of weight stability or gain, over a period of 10 years, on telomere length, sirtuin 1 and 6 expression, and carotid intima media thickness. Methods: We studied 148 healthy adults (age range 20–59 years; 101 females) who had an objective record of their weight 10 years before. They were classified as weight losers, weight maintainers, weight gainers and extreme weight gainers. A fasting blood sample was obtained for routine laboratory and isolation of peripheral blood mononuclear cells, to extract DNA and RNA, and to measure telomere length and sirtuin 1 and 6 expression, respectively. Carotid intima media thickness was measured by ultrasound. Body composition was measured by Dual-energy X-ray absorptiometry. Results: In the 10-year period, 24 participants lost weight (17 females), 65 maintained weight (41 females), 25 gained weight (15 females) and 34 were extreme weight gainers (28 females). Female weight gainers had a higher body mass index, waist circumference, total body fat and homeostatic model assessment insulin resistance. Male weight gainers had a higher hip circumference and total body fat. No differences in telomere length, sirtuin 1 expression and carotid intima media thickness were observed between weight gainers and maintainers. Conclusions: No effect of weight maintenance or gain was observed on metabolic and vascular markers of ageing.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherThe British Dietetic Associationen_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectWighten_US
Keywordsdc.subjectTelomeresen_US
Keywordsdc.subjectSirtuinsen_US
Keywordsdc.subjectEnergy restrictionen_US
Keywordsdc.subjectCarotid intima media thicknessen_US
Títulodc.titleEffect of weight maintenance or gain in a 10 years period over telomere length, sirtuin 1 and 6 expression and carotid intima media thicknessen_US
Document typedc.typeArtículo de revistaen_US


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile