Effect of weight maintenance or gain in a 10 years period over telomere length, sirtuin 1 and 6 expression and carotid intima media thickness
Bunout Barnett, Daniel
Barrera Acevedo, Maria
Maza Cave, María Pía de la
Hirsch Birn, Sandra
Cita de ítem
Journal of Human Nutrition and Dietetics, Volumen: 28 Número: 2 Páginas: 155-164, Apr 2015
Artículo de publicación ISI
Background: Lack of weight gain throughout adult life could mimic the
beneficial effects of energy restriction in humans. The present study aimed
to assess the effects of weight stability or gain, over a period of 10 years, on
telomere length, sirtuin 1 and 6 expression, and carotid intima media
Methods: We studied 148 healthy adults (age range 20–59 years; 101
females) who had an objective record of their weight 10 years before. They
were classified as weight losers, weight maintainers, weight gainers and
extreme weight gainers. A fasting blood sample was obtained for routine laboratory
and isolation of peripheral blood mononuclear cells, to extract DNA
and RNA, and to measure telomere length and sirtuin 1 and 6 expression,
respectively. Carotid intima media thickness was measured by ultrasound.
Body composition was measured by Dual-energy X-ray absorptiometry.
Results: In the 10-year period, 24 participants lost weight (17 females), 65
maintained weight (41 females), 25 gained weight (15 females) and 34 were
extreme weight gainers (28 females). Female weight gainers had a higher
body mass index, waist circumference, total body fat and homeostatic model
assessment insulin resistance. Male weight gainers had a higher hip circumference
and total body fat. No differences in telomere length, sirtuin 1
expression and carotid intima media thickness were observed between
weight gainers and maintainers.
Conclusions: No effect of weight maintenance or gain was observed on
metabolic and vascular markers of ageing.