Body mass index, iron absorption and iron status in childbearing age women
Author
dc.contributor.author
Mujica Coopman, María
Author
dc.contributor.author
Brito, Alex
Author
dc.contributor.author
López de Romaña, Daniel
Author
dc.contributor.author
Pizarro Aguirre, Fernando
Author
dc.contributor.author
Olivares Grohnert, Manuel
Admission date
dc.date.accessioned
2015-08-18T19:50:10Z
Available date
dc.date.available
2015-08-18T19:50:10Z
Publication date
dc.date.issued
2015
Cita de ítem
dc.identifier.citation
Journal of Trace Elements in Medicine and Biology Volume 30, April 2015, Pages 215–219
en_US
Identifier
dc.identifier.other
DOI: 10.1016/j.jtemb.2014.03.008
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/132880
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
Background: The prevalence of obesity has increased at an alarming rate worldwide. Some studies have
observed an association between iron (Fe) deficiency (ID) and obesity, however more research is needed.
Objective: To assess whether body mass index (BMI) is associated with both Fe absorption and Fe status.
Methods: A cross sectional sample of 318 Chilean childbearing age women was studied. The women
received either a single dose of 0.5 mg of Fe (n = 137, group 1) or 3 mg of Fe plus ascorbic acid (1:2 molar
ratio) (n = 181, group 2), both as FeSO4 with labeled radioisotopes. Fe absorption was assessed through
radio Fe erythrocyte incorporation. Fe status was determined by hemoglobin (Hb), mean corpuscular
volume, serum Fe, total iron binding capacity, transferrin saturation, erythrocyte Zn protoporphyrin and
serum ferritin (SF).
Results: 29%, 47% and 24% of the women were classified as normal, overweight or obese, respectively. Fe
absorption was significantly lower in obese women (p < 0.05). In group 1, the geometric mean and range
±1 SD of the percentage of Fe absorption for normal-weight women was 32.9% vs. 19.7% in obese. For
group 2, this percentage was 36% vs. 30%, respectively (2-way ANOVA: BMI classification and Fe dose
p < 0.05; interaction p = 0.34). Although Fe absorption was lower in obese women, they had higher SF
(p < 0.01) and Hb (p < 0.05) concentrations.
Conclusion: Although we did not observe a relationship between BMI and Fe status, obese women displayed
lower Fe absorption compared with overweight and normal weight women, possibly due to
subclinical inflammation associated with obesity.
en_US
Patrocinador
dc.description.sponsorship
The study was partially supported by grants from Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) Chile #. 1950242, 1040879, 1070665.