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Authordc.contributor.authorMena, Natalia P. 
Authordc.contributor.authorGarcía Beltrán, Olimpo 
Authordc.contributor.authorLourido, Fernanda 
Authordc.contributor.authorUrrutia, Pamela J. 
Authordc.contributor.authorMena, Raúl 
Authordc.contributor.authorCastro Castillo, Vicente 
Authordc.contributor.authorCassels Niven, Bruce
Authordc.contributor.authorNúñez González, Marco 
Cita de ítemdc.identifier.citationBiochemical and Biophysical Research Communications 463 (2015) 787-792en_US
Identifierdc.identifier.otherDOI: 10.1016/j.bbrc.2015.06.014
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractAbundant evidence indicates that iron accumulation, oxidative damage and mitochondrial dysfunction are common features of Huntington's disease, Parkinson's disease, Friedreich's ataxia and a group of disorders known as Neurodegeneration with Brain Iron Accumulation. In this study, we evaluated the effectiveness of two novel 8-OH-quinoline-based iron chelators, Q1 and Q4, to decrease mitochondrial iron accumulation and oxidative damage in cellular and animal models of PD. We found that at sub-micromolar concentrations, Q1 selectively decreased the mitochondrial iron pool and was extremely effective in protecting against rotenone-induced oxidative damage and death. Q4, in turn, preferentially chelated the cytoplasmic iron pool and presented a decreased capacity to protect against rotenone-induced oxidative damage and death. Oral administration of Q1 to mice protected substantia nigra pars compacta neurons against oxidative damage and MPTP-induced death. Taken together, our results support the concept that oral administration of Q1 is a promising therapeutic strategy for the treatment of NBIA.en_US
Patrocinadordc.description.sponsorshipCONICYT, Chile 3654593 FONDECYT 1130068 Program of Associative Research ACT1114en_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectIron chelationen_US
Keywordsdc.subjectParkinson's diseaseen_US
Títulodc.titleThe novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal deathen_US
Document typedc.typeArtículo de revistaen_US

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile