| Author | dc.contributor.author | Wilson, Carlos | |
| Author | dc.contributor.author | Núñez González, Marco | |
| Author | dc.contributor.author | González Billault, Christian | |
| Admission date | dc.date.accessioned | 2015-11-04T13:20:09Z | |
| Available date | dc.date.available | 2015-11-04T13:20:09Z | |
| Publication date | dc.date.issued | 2015 | |
| Cita de ítem | dc.identifier.citation | Journal of Cell Science Volumen: 128 Número: 16 Aug 2015 | en_US |
| Identifier | dc.identifier.other | DOI: 10.1242/jcs.168567 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/134825 | |
| General note | dc.description | Artículo de publicación ISI | en_US |
| General note | dc.description | Sin acceso a texto completo | |
| Abstract | dc.description.abstract | Reactive oxygen species (ROS) produced by the NADPH oxidase (NOX) complex play
important physiological and pathological roles in neurotransmission and neurodegeneration,
respectively. However, the contribution of ROS to the molecular mechanisms involved in
neuronal polarity and axon elongation is not well understood. In this work, we found that loss of
NOX complex function altered neuronal polarization and decreased axonal length by a
mechanism that involves actin cytoskeleton dynamics. These results indicate that physiological
levels of ROS produced by the NOX complex modulate hippocampal neuronal polarity and
axonal growth in vitro. | en_US |
| Patrocinador | dc.description.sponsorship | Comision Nacional de Investigacion Cientifica y Tecnologica
(CONICYT)
ACT-1114
Fondecyt 1140325
CONICYT doctoral fellowship 21120221 | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | Company of Biologists Ltd. | en_US |
| Keywords | dc.subject | NOX | en_US |
| Keywords | dc.subject | ROS | en_US |
| Keywords | dc.subject | Neuronal polarity | en_US |
| Keywords | dc.subject | Actin cytoskeleton | en_US |
| Título | dc.title | Contribution of NADPH oxidase to the establishment of hippocampal neuronal polarity in culture | en_US |
| Document type | dc.type | Artículo de revista | |
