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Authordc.contributor.authorSteinmaus, Craig 
Authordc.contributor.authorCastriota, Felicia 
Authordc.contributor.authorFerreccio, Catterina 
Authordc.contributor.authorSmith, Allan H. 
Authordc.contributor.authorYuan, Yan 
Authordc.contributor.authorLiaw, Jane 
Authordc.contributor.authorAcevedo, Johanna 
Authordc.contributor.authorPérez, Liliana 
Authordc.contributor.authorMeza, Rodrigo 
Authordc.contributor.authorCalcagno, Sergio 
Authordc.contributor.authorUauy Dagach-Imbarack, Ricardo 
Authordc.contributor.authorSmith, Martyn T. 
Admission datedc.date.accessioned2015-12-23T03:16:13Z
Available datedc.date.available2015-12-23T03:16:13Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationEnvironmental Research 142 (2015) 594-601en_US
Identifierdc.identifier.otherDOI: 10.1016/j.envres.2015.07.021
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/135951
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractBackground: Elevated body mass index (BMI) is a risk factor for cardiovascular disease, diabetes, cancer, and other diseases. Inflammation or oxidative stress induced by high BMI may explain some of these effects. Millions of people drink arsenic-contaminated water worldwide, and ingested arsenic has also been associated with inflammation, oxidative stress, and cancer. Objectives: To assess the unique situation of people living in northern Chile exposed to high arsenic concentrations in drinking water and investigate interactions between arsenic and BMI, and associations with lung and bladder cancer risks. Methods: Information on self-reported body mass index (BMI) at various life stages, smoking, diet, and lifetime arsenic exposure was collected from 532 cancer cases and 634 population-based controls. Results: In subjects with BMIs < 90th percentile in early adulthood (27.7 and 28.6 kg/m(2) in males and females, respectively), odds ratios (OR) for lung and bladder cancer combined for arsenic concentrations of < 100, 100-800 and > 800 mu g/L were 1.00, 1.64 (95% CI, 1.19-227), and 3.12 (2.30-4.22). In subjects with BMIs >= 90th percentile in early adulthood, the corresponding ORs were higher: 1.00, 1.84 (0.75-4.52), and 9.37 (2.88-30.53), respectively (synergy index=4.05, 95% Cl, 1.27-12.88). Arsenic-related cancer ORs > 20 were seen in those with elevated BMIs in both early adulthood and in later life. Adjustments for smoking, diet, and other factors had little impact. Conclusion: These findings provide novel preliminary evidence supporting the notion that environmentally-related cancer risks may be markedly increased in people with elevated BMIs, especially in those with an elevated BMI in early-life.en_US
Patrocinadordc.description.sponsorshipUS National Institute of Environmental Health Sciences 5R01ES014032 P42ES04705en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherElsevieren_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectArsenicen_US
Keywordsdc.subjectBMIen_US
Keywordsdc.subjectBladder canceren_US
Keywordsdc.subjectCanceren_US
Keywordsdc.subjectChileen_US
Keywordsdc.subjectDrinking wateren_US
Keywordsdc.subjectInflammationen_US
Keywordsdc.subjectLung canceren_US
Keywordsdc.subjectObesityen_US
Títulodc.titleObesity and excess weight in early adulthood and high risks of arsenic-related cancer in later lifeen_US
Document typedc.typeArtículo de revista


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile