The influence of platelet-derived products on angiogenesis and tissue repair: a concise update
Author
dc.contributor.author
Martínez, Constanza E.
Author
dc.contributor.author
Smith, Patricio C.
Author
dc.contributor.author
Palma Alvarado, Verónica
Admission date
dc.date.accessioned
2016-01-14T20:07:04Z
Available date
dc.date.available
2016-01-14T20:07:04Z
Publication date
dc.date.issued
2015
Cita de ítem
dc.identifier.citation
Frontiers in Physiology Volumen: 6 Número de artículo: 290 Oct 2015
en_US
Identifier
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DOI: 10.3389/fphys.2015.00290
Identifier
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https://repositorio.uchile.cl/handle/2250/136527
General note
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Artículo de publicación ISI
en_US
Abstract
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Platelet degranulation allows the release of a large amount of soluble mediators, is an essential step for wound healing initiation, and stimulates clotting, and angiogenesis. The latter process is one of the most critical biological events observed during tissue repair, increasing the growth of blood vessels in the maturing wound. Angiogenesis requires the action of a variety of growth factors that act in an appropriate physiological ratio to assure functional blood vessel restoration. Platelets release main regulators of angiogenesis: Vascular Endothelial Growth Factors (VEGFs), basic fibroblast growth factor (FGF-2), and Platelet derived growth factors (PDGFs), among others. In order to stimulate tissue repair, platelet derived fractions have been used as an autologous source of growth factors and biomolecules, namely Platelet Rich Plasma (PRP), Platelet Poor Plasma (PPP), and Platelet Rich Fibrin (PRF). The continuous release of these growth factors has been proposed to promote angiogenesis both in vitro and in vivo. Considering the existence of clinical trials currently evaluating the efficacy of autologous PRP, the present review analyses fundamental questions regarding the putative role of platelet derived fractions as regulators of angiogenesis and evaluates the possible clinical implications of these formulations.
en_US
Patrocinador
dc.description.sponsorship
National Fund for Scientific and Technological Development of The Chilean Government (FONDECYT)
11121294
1130618
1140697
Fondo de Fomento al Desarrollo Cientifico y Tecnologico (FONDEF)
D09E1047