Evaluating 5-Nitrothiazoles as Trypanocidal Agents
| Author | dc.contributor.author | O'Shea, Iván P. | |
| Author | dc.contributor.author | Shahed, Mohammed | |
| Author | dc.contributor.author | Aguilera Venegas, Benjamín | |
| Author | dc.contributor.author | Wilkinson, Shane R. | |
| Admission date | dc.date.accessioned | 2016-06-13T19:02:21Z | |
| Available date | dc.date.available | 2016-06-13T19:02:21Z | |
| Publication date | dc.date.issued | 2016 | |
| Cita de ítem | dc.identifier.citation | Antimicrobial Agents and Chemotherapy Volumen: 60 Número: 2 Páginas: 1137-1140 | en_US |
| Identifier | dc.identifier.other | DOI: 10.1128/AAC.02006-15 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/138764 | |
| General note | dc.description | Artículo de publicación ISI | en_US |
| General note | dc.description | Sin acceso a texto completo | |
| Abstract | dc.description.abstract | The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocyclic drugs may represent a new lead in the treatment of human African trypanosomiasis. | en_US |
| Patrocinador | dc.description.sponsorship | Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) 3130364 FONDECYT grant | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | Amer Soc Microbiology | en_US |
| Type of license | dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| Título | dc.title | Evaluating 5-Nitrothiazoles as Trypanocidal Agents | en_US |
| Document type | dc.type | Artículo de revista |
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