Calcium, Reactive Oxygen Species, and Synaptic Plasticity

Abstract

In this review article, we address how activity-dependent Ca2+ signaling is crucial for hippocampal synaptic/structural plasticity and discuss how changes in neuronal oxidative state affect Ca2+ signaling and synaptic plasticity. We also analyze current evidence indicating that oxidative stress and abnormal Ca2+ signaling contribute to age-related synaptic plasticity deterioration.