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Authordc.contributor.authorSepúlveda, Beatriz 
Authordc.contributor.authorQuispe, Cristina 
Authordc.contributor.authorSimirgiotis, Mario 
Authordc.contributor.authorGarcía Beltrán, Olimpo 
Authordc.contributor.authorAreche Medina, Carlos 
Admission datedc.date.accessioned2016-12-15T19:08:07Z
Available datedc.date.available2016-12-15T19:08:07Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationBioorganic & Medicinal Chemistry Letters. Volumen: 26 Número: 14 Páginas: 3220-3222es_ES
Identifierdc.identifier.other10.1016/j.bmcl.2016.05.081
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/141915
Abstractdc.description.abstractMulinane diterpenoids isolated from Azorella species have displayed gastroprotective effects in animal models. In this study we have transformed the main constituent, mulin-11,13-dien-20 oic acid from this plant using the filamentous fungus Mucor plumbeus and a beta-cyclodextrin inclusion complex and we have obtained two main products with good yields (33% and 15% for compound 4 and 5, respectively) for further preparation of semisynthetic derivatives to evaluate their gastroprotective effects. In addition, one of the compounds isolated from Azorella cuatrecasasii was new (9-epi-13 alpha-hydroxymulinene 1). Six new derivatives 4a-4c and 5a-5c were then prepared by simple chemical transformations. The structures of all compounds were elucidated by spectroscopic means based on 1D and 2D-NMR techniques. Some 8 diterpenes were evaluated for their gastroprotective effects in the ethanol/HCl-induced ulcer model in mice at 20 mg/kg. The highest gastroprotective activity was shown by 7 alpha,16-dihydroxymulin-11,13-dien- 20-oic acid 5, which was higher than the reference drug lansoprazole, while 16-hydroxymulin-11,13- dien-20-oic acid 4 was as active as lansoprazole. (C) 2016 Elsevier Ltd. All rights reserved.es_ES
Patrocinadordc.description.sponsorshipFONDECYT Iniciacion, Universidad de Ibague projectes_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherPergamon-Elsevier Sciencees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceBioorganic & Medicinal Chemistry Letterses_ES
Keywordsdc.subjectGastric ulceres_ES
Keywordsdc.subjectMulinanees_ES
Keywordsdc.subjectMicrobial transformationes_ES
Keywordsdc.subjectBiotransformationes_ES
Keywordsdc.subjectAzorella cuatrecasasiies_ES
Títulodc.titleGastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a b-cyclodextrin complex with microbial and chemical transformationses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorC. R. B.es_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile