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Authordc.contributor.authorAndrews, Mónica 
Authordc.contributor.authorLeiva, Elba 
Authordc.contributor.authorArredondo Olguin, Miguel Armando 
Admission datedc.date.accessioned2017-01-12T20:10:15Z
Available datedc.date.available2017-01-12T20:10:15Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationJournal of Trace Elements in Medicine and Biology 37 (2016) 25–30es_ES
Identifierdc.identifier.other10.1016/j.jtemb.2016.06.001
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/142407
Abstractdc.description.abstractObjective: We evaluated the relationship between the HO1 genotype, ferritin levels and the risk of type-2 diabetes and inflammation. Research methods: Eight hundred thirty-five individuals were evaluated and classified according to their nutritional status and the presence of type-2 diabetes: 153 overweight (OW); 62 obese (OB); 55 type-2 diabetes mellitus (DM); 202 OWDM; 239 OBDM and 124 controls (C). We studied biochemical (glycemia, insulin, lipid profile, liver enzyme, creatinine, hsCRP), hematological (hemoglobin, free erythrocyte protoporphyrin, transferrin receptor and serum Fe and ferritin) and oxidative stress (SOD, GHS and TBARS) parameters. We determined heme oxygenase activity and the (GT)(n) polymorphism in its gene promoter. Results: Individuals with diabetes, independent of nutritional status, showed high levels of ferritin and HO activity compared to control subjects. Allelic frequency was not different between the groups (Chi(2), NS) however, genotypes were different (Chi(2), P<0.001). The SS (short-short) genotype was higher in all DM individuals compared to controls and MM was higher in controls. SM (short-medium) genotype was an independent risk factor for DM in logistic regression analysis. We observed high risk for type-2 diabetes mellitus in the presence of SM genotype and high levels of ferritin (OR adjusted: 2.7; 1.9-3.6; p<0.001; compared to control group). It was also significantly related to inflammation. Conclusion: The SM genotype in HO1 gene promoter and ferritin levels were associated with higher risk for type-2 diabetes and for having a higher marker of inflammation, which is the main risk factor for the development of chronic diseases. Copyright (C) 2016 Elsevier GmbH. All rights reserved.es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevier GMBHes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceJournal of Trace Elements in Medicine and Biologyes_ES
Keywordsdc.subjectType-2 diabetes mellituses_ES
Keywordsdc.subjectIron; Ferritines_ES
Keywordsdc.subjectInflammationes_ES
Keywordsdc.subjectPolymorphismes_ES
Keywordsdc.subjectHeme oxygenasees_ES
Títulodc.titleShort repeats in the heme oxygenase 1 gene promoter is associated with increased levels of inflammation, ferritin and higher risk of type-2 diabetes mellituses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorC. R. B.es_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile