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Authordc.contributor.authorAlbala Brevis, Cecilia 
Authordc.contributor.authorÁngel Badillo, Bárbara Karen 
Authordc.contributor.authorLera Marques, Lydia 
Authordc.contributor.authorSánchez Reyes, Hugo 
Authordc.contributor.authorMárquez, Carlos 
Authordc.contributor.authorFuentes Guglielmetti, Patricio Alberto 
Cita de ítemdc.identifier.citationDementia and Geriatric Cognitive Disorders. Extra Volumen: 6 Número: 2 Páginas: 295-302es_ES
Abstractdc.description.abstractObjective: The aim was to study the role of leptin in the development of dementia. Methods: Follow-up of the ALEXANDROS cohorts, with baseline measurements in 2000. From 1,136 available subjects free of dementia at baseline, 667 subjects had frozen baseline blood samples for measuring leptin and soluble leptin receptor (sOB-R). The free leptin index (FLI) was calculated as the ratio of leptin to sOB-R. Dementia was defined as an MMSE score <22 and a score >5 in the Pfeffer Activities Questionnaire. Results: After 15 years of follow-up, 42 incident cases of dementia were identified. No difference in serum leptin was observed between people with and without dementia, but sOB-R was higher in demented than in nondemented subjects (sOB-R: 44.94 +/- 23.97 vs. 33.73 +/- 21.13 ng/ml). The adjusted risk for dementia increased, the higher the log sOB (hazard ratio = 3.58; 95% CI 1.72-7.45, p = 0.001). Conclusion: Lower availability of free leptin was found in demented than in nondemented people, suggesting a role of leptin in cognition. (C) 2016 The Author(s) Published by S. Karger AG, Baseles_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceDementia and Geriatric Cognitive Disorderses_ES
Keywordsdc.subjectSoluble leptin receptores_ES
Keywordsdc.subjectFree leptines_ES
Títulodc.titleLow Leptin Availability as a Risk Factor for Dementia in Chilean Older Peoplees_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorC. R. B.es_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile