Effectiveness of the management of major depressive episodes/disorder in adults with comorbid chronic physical diseases: a protocol for a systematic review and meta analysis
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2017Metadata
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Martínez, Pablo
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Effectiveness of the management of major depressive episodes/disorder in adults with comorbid chronic physical diseases: a protocol for a systematic review and meta analysis
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Abstract
Introduction Depression is a global-scale public
health problem, and a significant association has been
established between depression and chronic physical
diseases. This growing comorbidity poses a challenge to
healthcare systems. We aim to assess the effectiveness of
the management of major depressive episodes/disorder in
adults with comorbid chronic physical diseases.
Methods and analysis We will conduct a systematic
review and meta-analysis of randomised clinical trials.
Two databases MEDLINE and Cochrane Library (Cochrane
Database for Systematic Reviews and CENTRAL), as
well as the reference lists of the included articles, will
be searched for studies either in English or Spanish with
published results within the 2005–2015 period. Studies
must fulfil the following conditions: (1) participants
aged 18 years or older, diagnosed as having a major
depressive episodes/disorder according to standardised
criteria and chronic physical diseases; (2)interventions
(be it pharmacological, psychological, psychosocial or a
combination) must be compared with control conditions
(other ‘active’ intervention, treatment as usual, waiting list
or placebo); (3)and must report reduction in depressive
symptoms after treatment, response to treatment,
remission of major depressive episodes/disorder and
significant improvement in quality of life. Data extraction,
risk of bias evaluation, results summarisation and
quality of the evidence (GRADE) will be performed as
recommended by the Cochrane Collaboration. A qualitative
synthesis and a random effects meta-analysis will be
carried out. Effect sizes will be calculated (relative risk
and Cohen’s d), I2
and Q statistics will be employed to
study heterogeneity and publication bias analysis will be
performed. Subgroup analyses and meta-regression will
be carried out.
Ethics and dissemination Results are expected to be
published in specialised peer-reviewed journals (preferred
topics: Mental Health, Psychology, Psychiatry and/or
Systematic Reviews) and dissemination activities will be
targeted to all the healthcare providers.
Patrocinador
Chilean National Fund for Scientific and Technological Development (FONDECYT)
1130230
Fund for Innovation and Competitiveness (FIC) of the Chilean Ministry of Economy, Development, and Tourism, through the Millennium Scientific Initiative
IS130005
Program for Institutional Improvement - Universidad de Santiago de Chile of the Ministry of Education, through the Information Technology Innovation Centre for Social Applications (CITIAPS)
PMI USA 1204
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Artículo de publicación ISI
Quote Item
BMJ Open 2017; 7: e011249.
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