Low muscle mass is associated with cardiometabolic risk regardless of nutritional status in adolescents: a cross sectional study in a Chilean birth cohort
Author | dc.contributor.author | Burrows, Raquel | |
Author | dc.contributor.author | Correa Burrows, María Paulina | |
Author | dc.contributor.author | Reyes Jedlicki, Marcela | |
Author | dc.contributor.author | Blanco, Estela | |
Author | dc.contributor.author | Albala Brevis, Cecilia | |
Author | dc.contributor.author | Gahagan, S. | |
Admission date | dc.date.accessioned | 2018-06-18T14:31:06Z | |
Available date | dc.date.available | 2018-06-18T14:31:06Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Pediatric Diabetes 2017; 18 (8): 895–902 | es_ES |
Identifier | dc.identifier.other | 10.1111/pedi.12505 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/148944 | |
Abstract | dc.description.abstract | BackgroundIncreased cardiometabolic risk (CMR) is documented in obese and non-obese adolescents with low muscular fitness. However, the association of low muscle mass (LMM) with CMR, independent of weight status, has not been examined. We analyzed the relationship of LMM with CMR in adolescents, regardless of their weight status. Materials and MethodsObservational study in 660 adolescents. BMI, waist circumference (WC), arterial blood pressures (ABP) were measured. Total fat mass (TFM), total lean tissue (TLT), and appendicular skeletal muscle mass (ASM) were estimated (DXA). Fasting lipid profile, glucose, and insulin were measured. HOMA-IR was estimated. Metabolic Syndrome (MetS) was diagnosed (AHA/NHLBI/IDF). ROC analysis was performed to find the optimal cutoffs of TLT percentage for MetS diagnosis. Values below these cutoffs defined LMM. ANCOVA examined the association of LMM with selected cardiometabolic biomarkers. ResultsIn both sexes, TLT showed better sensitivity and specificity than ASM for MetS diagnosis. In males and females, TLT of 66.1% and 56.3%, respectively, were the optimal cutoff for MetS diagnosis. In the sample, 17.3% of males and 23.7% of females had LMM. In both sexes, adolescents with LMM had significantly higher values of WC, ABP, TG, TC/HDL, HOMA-IR, and MetSz-score than non-LMM participants. Adolescents with LMM, regardless nutritional status, had significantly increased values of MetSz-score, ABP, TG, TC/HDL-chol, and HOMA-IR than non-obese non-LMM adolescents. Adolescents having both obesity and LMM had the unhealthiest CMR profile. ConclusionIn adolescents, LMM was associated with higher CMR, regardless of nutritional status. In obese adolescents, LMM increased obesity-associated CMR. | es_ES |
Patrocinador | dc.description.sponsorship | National Heart, Lung and Blood Institute Advanced Human Capital Program | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Wiley | es_ES |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | * |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
Source | dc.source | Pediatric Diabetes | es_ES |
Keywords | dc.subject | Adolescents | es_ES |
Keywords | dc.subject | Cardiometabolic risk | es_ES |
Keywords | dc.subject | Low lean mass | es_ES |
Keywords | dc.subject | Metabolic syndrome | es_ES |
Keywords | dc.subject | Obesity | es_ES |
Título | dc.title | Low muscle mass is associated with cardiometabolic risk regardless of nutritional status in adolescents: a cross sectional study in a Chilean birth cohort | es_ES |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | tjn | es_ES |
Indexation | uchile.index | Artículo de publicación ISI | es_ES |
Indexation | uchile.index | Artículo de publicación SCOPUS |
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