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Fine tuning PERK signaling to control cell fate under stress

Authordc.contributor.authorUrra, Hery
Authordc.contributor.authorHetz Flores, Claudio
Admission datedc.date.accessioned2018-06-29T14:58:32Z
Available datedc.date.available2018-06-29T14:58:32Z
Publication datedc.date.issued2017
Cita de ítemdc.identifier.citationNature Structural & Molecular Biology, volume 24 number 10 October 2017es_ES
Identifierdc.identifier.other10.1038/nsmb.3478
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/149348
Abstractdc.description.abstractPERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to PERK's luminal domain. The PERK-CNPY2 axis was shown to enhance cell death under ER stress in vivo influence liver disease.es_ES
Patrocinadordc.description.sponsorshipFONDECYT 1140549 3160461 Millennium Institute P09-015-F FONDAP 15150012 U.S. Office of Naval Research-Global (ONR-G) N62909-16-1-2003 U.S. Air Force Office of Scientific Research FA9550-16-1-0384 BNIes_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherNaturees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceNature Structural & Molecular Biologyes_ES
Títulodc.titleFine tuning PERK signaling to control cell fate under stresses_ES
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadortjnes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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