PERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to PERK's luminal domain. The PERK-CNPY2 axis was shown to enhance cell death under ER stress in vivo influence liver disease.
U.S. Office of Naval Research-Global (ONR-G)
U.S. Air Force Office of Scientific Research