Fine tuning PERK signaling to control cell fate under stress
Fine-tuning-PERK.pdf (8.962Mb)Abstract
PERK is a major sensor of the unfolded protein response controlling cell fate under endoplasmic reticulum (ER) stress. A new study reveals an additional step for optimal PERK signaling, involving the binding of CNPY2 to PERK's luminal domain. The PERK-CNPY2 axis was shown to enhance cell death under ER stress in vivo influence liver disease.
Patrocinador
FONDECYT
1140549
3160461
Millennium Institute
P09-015-F
FONDAP
15150012
U.S. Office of Naval Research-Global (ONR-G)
N62909-16-1-2003
U.S. Air Force Office of Scientific Research
FA9550-16-1-0384
BNI
Indexation
Artículo de publicación ISI
Quote Item
Nature Structural & Molecular Biology, volume 24 number 10 October 2017
Collections
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile