Monitorización terapéutica de antimicrobianos en pediatría. Revisión de la experiencia latinoamericana
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2018Metadata
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Zylbersztajn, Brenda
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Monitorización terapéutica de antimicrobianos en pediatría. Revisión de la experiencia latinoamericana
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Abstract
This review summarizes recommendations of therapeutic monitoring of three antimicrobials based in regional
data: vancomycin, amikacin and voriconazole in pediatric population. Regional evidence agrees with international
literature regarding the requirement of higher daily doses than 40 mg/kg/day of vancomycin, as well as with the
possibility of use one daily doses of amikacin and to recommend higher doses of voriconazole compared to the
initially recommended doses of 8 mg/kg/day. Local data on the pharmacokinetic/pharmacodynamic behavior of
various antimicrobials in pediatrics are of great value for dosing adjustment in our pediatric population. More
studies in therapeutic monitoring in the use of antimicrobials in pediatrics should be performed in order to allow
the generation of adequate treatment guidelines for this age group.
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URI: https://repositorio.uchile.cl/handle/2250/150214
DOI: http://dx.doi.org/10.4067/s0716-10182018000100022
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Rev Chilena Infectol 2018; 35 (1): 22-28
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