Show simple item record

Authordc.contributor.authorBernal Sore, Izela 
Authordc.contributor.authorNavarro Márquez, Mario F. 
Authordc.contributor.authorOsorio Fuentealba, César 
Authordc.contributor.authorDíaz Castro, Francisco 
Authordc.contributor.authorCampo, Andrea del 
Authordc.contributor.authorDonoso Barraza, Camila 
Authordc.contributor.authorPorras Espinoza, Omar 
Authordc.contributor.authorLavandero González, Sergio
Authordc.contributor.authorTroncoso Cotal, Rodrigo 
Admission datedc.date.accessioned2018-07-26T22:43:56Z
Available datedc.date.available2018-07-26T22:43:56Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationMolecular and Cellular Endocrinology, 461 (2018): 277-283es_ES
Identifierdc.identifier.other10.1016/j.mce.2017.09.028
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/150372
Abstractdc.description.abstractMifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic treatment-induced obesity. However, the mechanisms through which Mifepristone produces its beneficial effects are not completely elucidated. Purpose: To determine the effects of mifepristone on insulin-stimulated glucose uptake on a model of L6 rat-derived skeletal muscle cells. Results: Mifepristone enhanced insulin-dependent glucose uptake, GLUT4 translocation to the plasma membrane and Akt Ser(473) phosphorylation in L6 myotubes. In addition, mifepristone reduced oxygen consumption and ATP levels and increased AMPIC Thr(172) phosphorylation. The knockdown of AMPK prevented the effects of mifepristone on insulin response. Conclusions: Mifepristone enhanced insulin-stimulated glucose uptake through a mechanism that involves a decrease in mitochondria! function and AMPK activation in skeletal muscle cells.es_ES
Patrocinadordc.description.sponsorshipFONDECYT 1161156 11130424 3140443 11130285 FONDAP grant 15130011 ACT1411es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceMolecular and Cellular Endocrinologyes_ES
Keywordsdc.subjectMifepristonees_ES
Keywordsdc.subjectRU486es_ES
Keywordsdc.subjectMitochondriaes_ES
Keywordsdc.subjectInsulines_ES
Keywordsdc.subjectAMPKes_ES
Keywordsdc.subjectL6 rat cellses_ES
Títulodc.titleMifepristone enhances insulin stimulated Akt phosphorylation and glucose uptake in skeletal muscle cellses_ES
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadortjnes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile