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MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells
Autor | dc.contributor.author | Villablanca, Eduardo J. | |
Autor | dc.contributor.author | Wang, Sen | |
Autor | dc.contributor.author | De Calisto, Jaime | |
Autor | dc.contributor.author | Gomes, Daniel C.O. | |
Autor | dc.contributor.author | Kane, Maureen A. | |
Autor | dc.contributor.author | Napoli, Joseph L. | |
Autor | dc.contributor.author | Blaner, William S. | |
Autor | dc.contributor.author | Kagechika, Hiroyuki | |
Autor | dc.contributor.author | Blomhoff, Rune | |
Autor | dc.contributor.author | Rosemblatt Silber, Mario César | |
Autor | dc.contributor.author | Bono Merino, María Rosa | |
Autor | dc.contributor.author | Von Andrian, Ulrich H. | |
Autor | dc.contributor.author | Mora, J. Rodrigo | |
Fecha ingreso | dc.date.accessioned | 2018-12-20T14:06:14Z | |
Fecha disponible | dc.date.available | 2018-12-20T14:06:14Z | |
Fecha de publicación | dc.date.issued | 2011 | |
Cita de ítem | dc.identifier.citation | Gastroenterology, Volumen 141, Issue 1, 2018, Pages 176-185 | |
Identificador | dc.identifier.issn | 15280012 | |
Identificador | dc.identifier.issn | 00165085 | |
Identificador | dc.identifier.other | 10.1053/j.gastro.2011.04.010 | |
Identificador | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/153866 | |
Resumen | dc.description.abstract | Background & Aims: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting cells. We investigated whether RA functions in a positive-feedback loop in DC to induce its own synthesis. Methods: We measured levels of retinoids in intestinal tissues from mice and assessed the role of RA in the functional specialization of gut-associated DC in cell cultures and mice. We used pharmacologic antagonists to determine the signaling pathways involved in regulation of DC and used MyD88-/- mice to determine the contribution of Toll-like receptor signaling in RA-mediated effects on DC. Results: The concentration of retinoids decreased in a proximal-to-distal gradient along the intestine, which correlated with the activity of gut-specific DC. Importantly, RA regulated the ability of gut-associated | |
Idioma | dc.language.iso | en | |
Publicador | dc.publisher | W.B. Saunders | |
Tipo de licencia | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link a Licencia | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Fuente | dc.source | Gastroenterology | |
Palabras claves | dc.subject | IBD | |
Palabras claves | dc.subject | Immune Response | |
Palabras claves | dc.subject | Inflammation | |
Palabras claves | dc.subject | Mouse Model | |
Título | dc.title | MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells | |
Tipo de documento | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
Catalogador | uchile.catalogador | SCOPUS | |
Indización | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI |
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