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Autordc.contributor.authorVillablanca, Eduardo J. 
Autordc.contributor.authorWang, Sen 
Autordc.contributor.authorDe Calisto, Jaime 
Autordc.contributor.authorGomes, Daniel C.O. 
Autordc.contributor.authorKane, Maureen A. 
Autordc.contributor.authorNapoli, Joseph L. 
Autordc.contributor.authorBlaner, William S. 
Autordc.contributor.authorKagechika, Hiroyuki 
Autordc.contributor.authorBlomhoff, Rune 
Autordc.contributor.authorRosemblatt Silber, Mario César 
Autordc.contributor.authorBono Merino, María Rosa 
Autordc.contributor.authorVon Andrian, Ulrich H. 
Autordc.contributor.authorMora, J. Rodrigo 
Fecha ingresodc.date.accessioned2018-12-20T14:06:14Z
Fecha disponibledc.date.available2018-12-20T14:06:14Z
Fecha de publicacióndc.date.issued2011
Cita de ítemdc.identifier.citationGastroenterology, Volumen 141, Issue 1, 2018, Pages 176-185
Identificadordc.identifier.issn15280012
Identificadordc.identifier.issn00165085
Identificadordc.identifier.other10.1053/j.gastro.2011.04.010
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/153866
Resumendc.description.abstractBackground & Aims: Gut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal tract and promotes the differentiation of Foxp3+ regulatory T cells and IgA antibody-secreting cells. We investigated whether RA functions in a positive-feedback loop in DC to induce its own synthesis. Methods: We measured levels of retinoids in intestinal tissues from mice and assessed the role of RA in the functional specialization of gut-associated DC in cell cultures and mice. We used pharmacologic antagonists to determine the signaling pathways involved in regulation of DC and used MyD88-/- mice to determine the contribution of Toll-like receptor signaling in RA-mediated effects on DC. Results: The concentration of retinoids decreased in a proximal-to-distal gradient along the intestine, which correlated with the activity of gut-specific DC. Importantly, RA regulated the ability of gut-associated
Idiomadc.language.isoen
Publicadordc.publisherW.B. Saunders
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceGastroenterology
Palabras clavesdc.subjectIBD
Palabras clavesdc.subjectImmune Response
Palabras clavesdc.subjectInflammation
Palabras clavesdc.subjectMouse Model
Títulodc.titleMyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells
Tipo de documentodc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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