A BK (Slo1) channel journey from molecule to physiology
Author
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Contreras, Gustavo F.
Author
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Castillo, Karen
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Enrique, Nicolás
Author
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Carrasquel Ursulaez, Willy
Author
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Castillo, Juan Pablo
Author
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Milesi, Verónica
Author
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Neely, Alan
Author
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Alvarez, Osvaldo
Author
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Ferreira, Gonzalo
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Gonzalez, Carlos
Author
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Latorre, Ramón
Admission date
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2018-12-20T14:06:21Z
Available date
dc.date.available
2018-12-20T14:06:21Z
Publication date
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2013
Cita de ítem
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Channels, Volumen 7, Issue 6, 2018,
Identifier
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19336969
Identifier
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19336950
Identifier
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10.4161/chan.26242
Identifier
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https://repositorio.uchile.cl/handle/2250/153920
Abstract
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Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and non-neuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK channels provide a damping mechanism for excitatory signals. Molecular modulation of these channels by alternative splicing, auxiliary subunits and post-translational modifications showed that these channels are subjected to many mechanisms that add diversity to the BK channel ́ subunit gene. This complexity of interactions modulates BK channel gating, modifying the energetic barrier of voltage sensor domain activation and channel opening. Regions for voltage as well as Ca2+ sensitivity have been identified, and the crystal structure generated by the 2 RCK domains contained in the C-terminal of the channel has been described. The linkage of these channels to many intracellular metabolites and pathways, as well as their modulation by extracellular natural agents, has bee