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Author | dc.contributor.author | Areche, Carlos | |
Author | dc.contributor.author | Sepúlveda, Beatriz | |
Author | dc.contributor.author | Martin, Aurelio San | |
Author | dc.contributor.author | García Beltrán, Olimpo | |
Author | dc.contributor.author | Simirgiotis, Mario J. | |
Author | dc.contributor.author | Cañete, Alvaro | |
Admission date | dc.date.accessioned | 2018-12-20T14:06:23Z | |
Available date | dc.date.available | 2018-12-20T14:06:23Z | |
Publication date | dc.date.issued | 2014 | |
Cita de ítem | dc.identifier.citation | Organic and Biomolecular Chemistry, Volumen 12, Issue 33, 2018, Pages 6406-6413 | |
Identifier | dc.identifier.issn | 14770520 | |
Identifier | dc.identifier.other | 10.1039/c4ob00966e | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/153933 | |
Abstract | dc.description.abstract | Four new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13α-hydroxyazorellane, 13β- hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy- 16,20-dioic acid were isolated from the Chilean plant Azorella trifurcata. One of the new metabolites isolated, 7α-acetoxy-9-epi-13β- hydroxymulinane, possesses a new trans-syn-trans arrangement in a tricyclic ring system not previously encountered in nature. Among the mulinane diterpenoids isolated, mulin-11,13-dien-20-oic acid showed the gastroprotective effect on HCl-EtOH-induced gastric lesions in mice (ED50 = 55 mg kg -1). Regarding the mode of gastroprotective action for this active compound, its effect was reduced by pre-treatment of the mice with indomethacin and N-ethylmaleimide, suggesting that prostaglandins and sulfhydryl compounds are positively involved in the gastroprotective activity using this model. © the Partner Organisations 2014. | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Royal Society of Chemistry | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Organic and Biomolecular Chemistry | |
Keywords | dc.subject | Biochemistry | |
Keywords | dc.subject | Physical and Theoretical Chemistry | |
Keywords | dc.subject | Organic Chemistry | |
Título | dc.title | An unusual mulinane diterpenoid from the Chilean plant Azorella trifurcata (Gaertn) Pers | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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