Preliminary studies for ciclopirox olamine determination by thermal lens spectrophotometry

Abstract

© 2016 Elsevier B.V. The spectrophotometric kinetic methods are broadly used in the determination of drugs in several types of matrices. Thermal Lens Spectrometry (TLS) has demonstrated to be a sensitive indirect spectrophotometric technique used in the field of applied sciences, such as environmental and biochemical sciences. Ciclopirox olamine (CXO) is a synthetic fungicide that inhibits the growth of pathogenic dermatophytes. This work presents the results of CXO determination by TLS, through a kinetic method, based on the CXO oxidation with KMnO4 in alkaline medium to form manganate (MnO4 2-). The Thermal Lens (TL) effect was generated by a He-Ne laser (TEM00, 20 mW, 632 nm). The TLS measurements were performed on a single beam assembly with a lens of f = 7.5 cm focal distance and 10 Hz modulation frequency. The TL signal from the detector was acquired for each sample. The optimization was at 30 min reaction time, KMnO4 8.0 · 10-4 mol L-1 and Na2SO4 0.6 mol L-1. Under these conditi