The effect of diabetes, nutritional factors, and sex on rat liver and kidney mevalonate kinase, mevalonate-5-phosphate kinase, and mevalonate-5-pyrophosphate decarboxylase
Author
dc.contributor.author
Jabalquinto, Ana María
Author
dc.contributor.author
Cardemil, Emilio
Admission date
dc.date.accessioned
2018-12-20T14:08:14Z
Available date
dc.date.available
2018-12-20T14:08:14Z
Publication date
dc.date.issued
1981
Cita de ítem
dc.identifier.citation
Archives of Biochemistry and Biophysics, Volumen 210, Issue 1, 2018, Pages 132-139
Identifier
dc.identifier.issn
10960384
Identifier
dc.identifier.issn
00039861
Identifier
dc.identifier.other
10.1016/0003-9861(81)90173-9
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/154144
Abstract
dc.description.abstract
The activities of rat liver mevalonate kinase (EC 2.7.1.36), mevalonate-5-phosphate kinase (EC 2.7.4.2), and mevalonate-5-pyrophosphate decarboxylase (EC 4.1.1.33) decrease when rats are fasted, fed with a diet containing 2% cholesterol, or made diabetic. Enzyme activities are increased when the animals are fed with a diet containing 3% cholestyramine. In rat kidney, the enzyme activities are lowered in diabetic and fasted rats, but do not change in cholesterol or cholestyramine feeding. The results obtained with the liver enzymes, when taken tgether with those of other authors, indicate a coordinate variation in the activities of several enzymes in the biosynthesis of cholesterol that catalyze steps from acetyl coenzyme A to squalene. The behavior observed for the kidney enzymes support the view of common steps for the metabolism of mevalonate via the sterol and nonsterol pathways and indicate also coordinate variation in the activity of the enzymes investigated in this work. In femal
The effect of diabetes, nutritional factors, and sex on rat liver and kidney mevalonate kinase, mevalonate-5-phosphate kinase, and mevalonate-5-pyrophosphate decarboxylase