Effect of iron therapy on phagocytosis and bactericidal activity in neutrophils of iron-deficient infants
Author
dc.contributor.author
Walter,
Author
dc.contributor.author
Arredondo,
Author
dc.contributor.author
Arevalo,
Author
dc.contributor.author
Stekel,
Admission date
dc.date.accessioned
2018-12-20T14:08:21Z
Available date
dc.date.available
2018-12-20T14:08:21Z
Publication date
dc.date.issued
1986
Cita de ítem
dc.identifier.citation
American Journal of Clinical Nutrition, Volumen 44, Issue 6, 2018, Pages 877-882
Identifier
dc.identifier.issn
00029165
Identifier
dc.identifier.other
10.1093/ajcn/44.6.877
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/154193
Abstract
dc.description.abstract
Phagocytosis and bactericidal capacity of neutrophils were measured in 10 iron-deficient infants age 6-23 mo. All infants had hemoglobins < 11 mg/dL with low saturation of transferrin and serum ferritin but were otherwise in good health. Neutrophil function and iron status were assessed at O, 3-5, 15, 30, and 90 days of oral iron therapy. Phagocytosis was unaffected in iron deficiency and remained unchanged during therapy. Bactericidal capacity was severely impaired prior to treatment. After 3-5 days of ferrous sulfate administration, there was no significant improvement. At day 15 it returned to normal ranges and remained so at days 30 and 90. The sequence of events suggests that iron does not have a direct effect upon circulating neutrophils but, rather, that it is required during the development of neutrophils in the bone marrow.