Show simple item record

Authordc.contributor.authorFerreira, J. 
Authordc.contributor.authorColoma, L. 
Authordc.contributor.authorFones, E. 
Authordc.contributor.authorLetelier, M. E. 
Authordc.contributor.authorRepetto Scaramelli, Yolanda 
Authordc.contributor.authorMorello Casté, Antonio 
Authordc.contributor.authorAldunate, J. 
Cita de ítemdc.identifier.citationFEBS Letters, Volumen 234, Issue 2, 2018, Pages 485-488
Abstractdc.description.abstractThe antioxidant food additives 2(3)-tert-butyl-4-hydroxyanisole (BHA), 2,6-di(tert-butyl)-p-cresol (BHT) and the methyl and propyl esters of gallic acid inhibited Trypanosoma cruzi culture growth and oxygen consumption. The I50 values for growth and oxygen uptake with BHA were 0.284 and 0.400 and for BHT 0.083 and 0.235 mM, respectively. Moreover, BHA inhibited the respiration of several tumor cells, as well as of the procyclic and bloodstream trypomastigote forms of T. brucei brucei, with I50 in the range 0.29-0.52 mM. Inhibition of the parasites' oxygen uptake by BHA was not of the pure Michaelis-Menten type, but may be of a mixed form. It is postulated that these compounds are inhibitors because they resemble ubiquinone. © 1988.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceFEBS Letters
Keywordsdc.subject(Trypanosoma cruzi, Trypanosoma brucei, Tumor cell)
Keywordsdc.subjectRespiration inhibition
Títulodc.titleEffects of t-butyl-4-hydroxyanisole and other phenolic antioxidants on tumoral cells and Trypanosoma parasites
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile