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Authordc.contributor.authorGómez Skarmeta, José Luis 
Authordc.contributor.authorGlavic Maurer, Álvaro 
Authordc.contributor.authorCalle Mustienes, Elisa de la 
Authordc.contributor.authorModolell, Juan 
Authordc.contributor.authorMayor, Roberto 
Cita de ítemdc.identifier.citationEMBO Journal, Volumen 17, Issue 1, 2018, Pages 181-190
Abstractdc.description.abstractThe Drosophila homeoproteins Ara and Caup are members of a combination of factors (prepattern) that control the highly localized expression of the proneural genes achaete and scute. We have identified two Xenopus homologs of ara and caup, Xiro1 and Xiro2. Similarly to their Drosophila counterparts, they control the expression of proneural genes and, probably as a consequence, the size of the neural plate. Moreover, Xiro1 and Xiro2 are themselves controlled by noggin and retinoic acid and, similarly to ara and caup, they are overexpressed by expression in Xenopus embryos of the Drosophila cubitus interruptus gene. These and other findings suggest the conservation of at least part of the genetic cascade that regulates proneural genes, and the existence in vertebrates of a prepattern of factors important to control the differentiation of the neural plate.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceEMBO Journal
Keywordsdc.subjectNeural crest
Keywordsdc.subjectNeural plate
Keywordsdc.subjectProneural genes
Títulodc.titleXiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile