Xenopus brain factor-2 controls mesoderm, forebrain and neural crest development
Author
dc.contributor.author
Gómez Skarmeta, José Luis
Author
dc.contributor.author
Calle Mustienes, Elisa de la
Author
dc.contributor.author
Modolell, Juan
Author
dc.contributor.author
Mayor, Roberto
Admission date
dc.date.accessioned
2018-12-20T14:10:43Z
Available date
dc.date.available
2018-12-20T14:10:43Z
Publication date
dc.date.issued
1999
Cita de ítem
dc.identifier.citation
Mechanisms of Development, Volumen 80, Issue 1, 2018, Pages 15-27
Identifier
dc.identifier.issn
09254773
Identifier
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10.1016/S0925-4773(98)00190-7
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/154399
Abstract
dc.description.abstract
The forkhead type Brain-Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes. Indeed, Xbf2 overexpression caused partial axis duplication. Interference with BMP-4 signaling also occurs in isolated animal caps, since Xbf2 induces neural tissue. Within the neurula forebrain, Xbf2 and the related Xbf1 gene are expressed in the contiguous diencephalic and telencephalic territories, respectively, and each gene represses the other. Finally, Xbf2 seems to participate in the control of neural crest migration. Our data suggest that XBF2 interferes with BMP-4 signaling, both in mesoderm and ectoderm.