Interaction between glutathione and ampicillin: an a.c. polarographic method
Author
dc.contributor.author
Squella Serrano, Juan
Author
dc.contributor.author
Núñez Vergara, Luis
Admission date
dc.date.accessioned
2018-12-20T14:12:15Z
Available date
dc.date.available
2018-12-20T14:12:15Z
Publication date
dc.date.issued
1983
Cita de ítem
dc.identifier.citation
J. ElectroanaL Chem., and constituting Vol. 156 (1983)
Identifier
dc.identifier.issn
00220728
Identifier
dc.identifier.other
10.1016/S0022-0728(83)80677-9
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/154695
Abstract
dc.description.abstract
The interaction of glutathione with ampicillin was investigated by a new a.c. polarographic procedure. Ampicillin was found to interact strongly with glutathione. The stability constants were ascertained from the polarographic data, and the free energy change, ΔGo, the enthalpy change, ΔHo, and the entropy change, ΔSo, of the interaction were computed from the data at different temperatures. The introduction of the polarographic method to the study of interactions between molecules of biological significance (other than metal-ion complexes), and the possibility of GSH binding to ampicillin in vivo are the principal contributions of this work