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Authordc.contributor.authorSeligmann, Hervé 
Authordc.contributor.authorLabra, Antonieta 
Admission datedc.date.accessioned2018-12-20T14:13:59Z
Available datedc.date.available2018-12-20T14:13:59Z
Publication datedc.date.issued2013
Cita de ítemdc.identifier.citationBioSystems, Volumen 114, Issue 3, 2018, Pages 155-163
Identifierdc.identifier.issn18728324
Identifierdc.identifier.issn03032647
Identifierdc.identifier.other10.1016/j.biosystems.2013.09.002
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/155057
Abstractdc.description.abstractCodons expanded by a silent position (quadruplet or tetracodons) may solve the conundrum that at life's origins, the weak tricodon-anticodon interactions could not promote translation in the absence of complex ribosomes. Modern genomes have isolated tetracodons resulting from insertion mutations. Some bioinformatic analyses suggest that tetracoding stretches overlap with regular mitochondrial protein coding genes. These tetragenes are probably decoded by (antisense) tRNAs with expanded anticodons. They are GC-rich, which produce stronger basepairs than A:T interactions, suggesting expression at high temperatures. The hypothesis that tetracoding is an adaptation to high temperatures is tested here by comparing predicted mitochondrial tetracoding in Lepidosauria (lizards, amphisbaenia, and Sphenodon), in relation to body temperature, expecting more tetracoding in species with high body temperature. The association between tRNAs with expanded anticodons and tetracoding previously describe
Lenguagedc.language.isoen
Publisherdc.publisherElsevier Ireland Ltd
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBioSystems
Keywordsdc.subjectDevelopmental stability
Keywordsdc.subjectGenetic code expansion
Keywordsdc.subjectSuppressor tRNAs
Keywordsdc.subjectSynonymous codon usage
Keywordsdc.subjectTRNA cloverleaf structure
Títulodc.titleTetracoding increases with body temperature in Lepidosauria
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile