Coumarins of haplopappus multifolius and derivative as inhibitors of lox: Evaluation in-vitro and docking studies
Author
dc.contributor.author
Torres, Rene
Author
dc.contributor.author
Mascayano, Carolina
Author
dc.contributor.author
Núñez, Carolina
Author
dc.contributor.author
Modak, Brenda
Author
dc.contributor.author
Faini, Francesca
Admission date
dc.date.accessioned
2018-12-20T14:14:02Z
Available date
dc.date.available
2018-12-20T14:14:02Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
Journal of the Chilean Chemical Society, Volumen 58, Issue 4, 2018, Pages 2027-2030
Identifier
dc.identifier.issn
07179707
Identifier
dc.identifier.issn
07179324
Identifier
dc.identifier.other
10.4067/S0717-97072013000400027
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/155077
Abstract
dc.description.abstract
Several natural compounds containing a coumarin moiety have been reported. They have multiple biological activities, e. g. , as scavengers of reactive oxygen species (ROS) and to reduce the inflammatory processes by inhibition of enzymes like COX or LOX. A study was made of the inhibitory capacity of seven natural coumarins and one derivative of esculetin, against soybean 15-lipoxygenase (15-sLOX). The studied coumarins showed interesting degrees of inhibition compared to quercetin, a known LOX inhibitor. Docking studies of some compounds into the binding site of 15-sLOX and 5-hLOX were also made.